For Health Care Providers
Reporting MIS-C
Health care providers should report suspected cases of Multisystem Inflammatory Syndrome In Children (MIS-C) to KDHE within 4 hours of suspicion. Complete the Kansas Reportable Disease Form (PDF) then return as follows:
- Send via secure email to the Epi Hotline OR fax to 877-427-7318
- AND call the KDHE Epidemiology Hotline at 877-427-7317
Diagnosing MIS-C
The public health surveillance case definition for MIS-C is:
- An individual aged <21 years presenting with fever*, lab evidence of inflammation**, and evidence of clinically severe illness requiring hospitalization, with multisystem (≥2) organ involvement (cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological); AND
- No alternative plausible diagnoses; AND
- Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology, or antigen test; or exposure to a suspected or confirmed COVID-19 case within the 4 weeks prior to the onset of symptoms
*Fever ≥38.0ᵒC for ≥24 hours, or report of subjective fever lasting ≥24 hours
** Including, but not limited to, one or more of the following: an elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), fibrinogen, procalcitonin, d-dimer, ferritin, lactic acid dehydrogenase (LDH), or interleukin 6 (IL-6), elevated neutrophils, reduced lymphocytes and low albumin
Testing for MIS-C
There is currently not a test for MIS-C. Testing should be aimed at identifying evidence of inflammation as listed in the case definition. Detection of SARS-CoV-2 by RT-PCR or antigen test and when possible serologic testing is suggested. Serologic testing should be done prior to administering intravenous immunoglobulin (IVIG) or any other antibody treatments. AskMayoExpert: COVID-19: MIS-C in Children
Treatment for MIS-C
Currently there have been no studies comparing clinical efficacy of various treatment options. Treatments are mainly supportive care and care for the underlying inflammatory process. Supportive measures have included fluid resuscitation, inotropic support, respiratory support and, in rare cases, extracorporeal membranous oxygenation (ECMO). Anti-inflammatory measures have included the use of steroids and IVIG. Aspirin is commonly used for coronary artery involvement.
Coding for MIS-C
ICD-10-CM Diagnosis Code for MIS: M35.81. This is applicable to:
- MIS-C
- MIS-A
- Multisystem inflammatory syndrome in children
- Multisystem inflammatory syndrome in adults
- Pediatric inflammatory multisystem syndrome
- PIMS
Additional codes, if applicable:
- Sequalae of COVI-19 (B94.8)
- Personal history of COVID-19 (Z86.16)
- Exposure to COVID-19 or SARS-CoV-2 infection (Z20.822)
Resources to Share
Find fact sheets and resources to share with your patients in multiple languages on the CDC website.